<?xml version="1.0" encoding="UTF-8"?>
<!-- Made by IQ Info (http://www.iqinfo.com) 2006 Annual Reports of Dutch and International Companies -->
<!-- IQ Info XBRL Instance Generator 1.2.0 -->
<xbrli:xbrl xmlns:xbrli="http://www.xbrl.org/2003/instance"
xmlns:link="http://www.xbrl.org/2003/linkbase"
xmlns:xlink="http://www.w3.org/1999/xlink"
xmlns:ifrs-gp="http://xbrl.iasb.org/int/fr/ifrs/gp/2005-05-15"
xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<link:schemaRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="http://jaarverslag.info/annualreports/GALAPÁGOS/$File/GALAPÁGOS_IQInfo_taxonomy.xsd"/>
<!-- Context Info -->
<xbrli:context id="EJ2003">
<xbrli:entity>
<xbrli:identifier scheme="www.iqinfo.com/xbrl/">KVKBe</xbrli:identifier>
</xbrli:entity>
<xbrli:period>
<xbrli:instant>2003-12-31</xbrli:instant>
</xbrli:period>
</xbrli:context>
<xbrli:context id="EJ2004">
<xbrli:entity>
<xbrli:identifier scheme="www.iqinfo.com/xbrl/">KVKBe</xbrli:identifier>
</xbrli:entity>
<xbrli:period>
<xbrli:instant>2004-12-31</xbrli:instant>
</xbrli:period>
</xbrli:context>
<xbrli:context id="EJ2005">
<xbrli:entity>
<xbrli:identifier scheme="www.iqinfo.com/xbrl/">KVKBe</xbrli:identifier>
</xbrli:entity>
<xbrli:period>
<xbrli:instant>2005-12-31</xbrli:instant>
</xbrli:period>
</xbrli:context>
<xbrli:context id="J2004">
<xbrli:entity>
<xbrli:identifier scheme="www.iqinfo.com/xbrl/">KVKBe</xbrli:identifier>
</xbrli:entity>
<xbrli:period>
<xbrli:startDate>2004-01-01</xbrli:startDate>
<xbrli:endDate>2004-12-31</xbrli:endDate>
</xbrli:period>
</xbrli:context>
<xbrli:context id="J2005">
<xbrli:entity>
<xbrli:identifier scheme="www.iqinfo.com/xbrl/">KVKBe</xbrli:identifier>
</xbrli:entity>
<xbrli:period>
<xbrli:startDate>2005-01-01</xbrli:startDate>
<xbrli:endDate>2005-12-31</xbrli:endDate>
</xbrli:period>
</xbrli:context>
<xbrli:context id="J2006">
<xbrli:entity>
<xbrli:identifier scheme="www.iqinfo.com/xbrl/">KVKBe</xbrli:identifier>
</xbrli:entity>
<xbrli:period>
<xbrli:startDate>2006-01-01</xbrli:startDate>
<xbrli:endDate>2006-12-31</xbrli:endDate>
</xbrli:period>
</xbrli:context>
<xbrli:unit id="EUR">
<xbrli:measure>iso4217:EUR</xbrli:measure>
</xbrli:unit>
<!-- Financial Company Data generated bij IQ Info based on Annual Report -->
<ifrs-gp:PropertyPlantAndEquipmentNet decimals="-3" contextRef="EJ2004" unitRef="EUR">2625000</ifrs-gp:PropertyPlantAndEquipmentNet>
<ifrs-gp:IntangibleAssetsNet decimals="-3" contextRef="EJ2004" unitRef="EUR">447000</ifrs-gp:IntangibleAssetsNet>
<ifrs-gp:AssetsNonCurrentTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">3072000</ifrs-gp:AssetsNonCurrentTotal>
<ifrs-gp:Inventories decimals="-3" contextRef="EJ2004" unitRef="EUR">98000</ifrs-gp:Inventories>
<ifrs-gp:TradeAndOtherReceivablesNetCurrent decimals="-3" contextRef="EJ2004" unitRef="EUR">2169000</ifrs-gp:TradeAndOtherReceivablesNetCurrent>
<ifrs-gp:CashAndCashEquivalents decimals="-3" contextRef="EJ2004" unitRef="EUR">10274000</ifrs-gp:CashAndCashEquivalents>
<ifrs-gp:AssetsCurrentTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">12541000</ifrs-gp:AssetsCurrentTotal>
<ifrs-gp:AssetsTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">15613000</ifrs-gp:AssetsTotal>
<ifrs-gp:IssuedCapital decimals="-3" contextRef="EJ2004" unitRef="EUR">31557000</ifrs-gp:IssuedCapital>
<ifrs-gp:RetainedEarningsAccumulatedLosses decimals="-3" contextRef="EJ2004" unitRef="EUR">-21190000</ifrs-gp:RetainedEarningsAccumulatedLosses>
<ifrs-gp:EquityAttributableToEquityHoldersOfParent decimals="-3" contextRef="EJ2004" unitRef="EUR">10367000</ifrs-gp:EquityAttributableToEquityHoldersOfParent>
<ifrs-gp:EquityTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">10367000</ifrs-gp:EquityTotal>
<ifrs-gp:PostEmploymentBenefitObligationNonCurrent decimals="-3" contextRef="EJ2004" unitRef="EUR">1413000</ifrs-gp:PostEmploymentBenefitObligationNonCurrent>
<ifrs-gp:DeferredTaxLiabilities decimals="-3" contextRef="EJ2004" unitRef="EUR">225000</ifrs-gp:DeferredTaxLiabilities>
<ifrs-gp:LiabilitiesNonCurrentTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">1638000</ifrs-gp:LiabilitiesNonCurrentTotal>
<ifrs-gp:OtherFinancialLiabilitiesCurrent decimals="-3" contextRef="EJ2004" unitRef="EUR">106000</ifrs-gp:OtherFinancialLiabilitiesCurrent>
<ifrs-gp:CurrentTaxPayables decimals="-3" contextRef="EJ2004" unitRef="EUR">736000</ifrs-gp:CurrentTaxPayables>
<ifrs-gp:TradeAndOtherPayablesCurrent decimals="-3" contextRef="EJ2004" unitRef="EUR">2766000</ifrs-gp:TradeAndOtherPayablesCurrent>
<ifrs-gp:LiabilitiesCurrentTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">3608000</ifrs-gp:LiabilitiesCurrentTotal>
<ifrs-gp:LiabilitiesTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">5246000</ifrs-gp:LiabilitiesTotal>
<ifrs-gp:EquityAndLiabilitiesTotal decimals="-3" contextRef="EJ2004" unitRef="EUR">15613000</ifrs-gp:EquityAndLiabilitiesTotal>
<ifrs-gp:PropertyPlantAndEquipmentNet decimals="-3" contextRef="EJ2005" unitRef="EUR">9399000</ifrs-gp:PropertyPlantAndEquipmentNet>
<ifrs-gp:IntangibleAssetsNet decimals="-3" contextRef="EJ2005" unitRef="EUR">34350000</ifrs-gp:IntangibleAssetsNet>
<ifrs-gp:OtherFinancialAssetsNonCurrent decimals="-3" contextRef="EJ2005" unitRef="EUR">978000</ifrs-gp:OtherFinancialAssetsNonCurrent>
<ifrs-gp:TradeAndOtherReceivablesNetNonCurrent decimals="-3" contextRef="EJ2005" unitRef="EUR">291000</ifrs-gp:TradeAndOtherReceivablesNetNonCurrent>
<ifrs-gp:AssetsNonCurrentTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">45018000</ifrs-gp:AssetsNonCurrentTotal>
<ifrs-gp:Inventories decimals="-3" contextRef="EJ2005" unitRef="EUR">3142000</ifrs-gp:Inventories>
<ifrs-gp:TradeAndOtherReceivablesNetCurrent decimals="-3" contextRef="EJ2005" unitRef="EUR">9786000</ifrs-gp:TradeAndOtherReceivablesNetCurrent>
<ifrs-gp:CashAndCashEquivalents decimals="-3" contextRef="EJ2005" unitRef="EUR">23617000</ifrs-gp:CashAndCashEquivalents>
<ifrs-gp:AssetsCurrentTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">36545000</ifrs-gp:AssetsCurrentTotal>
<ifrs-gp:AssetsTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">81563000</ifrs-gp:AssetsTotal>
<ifrs-gp:IssuedCapital decimals="-3" contextRef="EJ2005" unitRef="EUR">69051000</ifrs-gp:IssuedCapital>
<ifrs-gp:OtherReserves decimals="-3" contextRef="EJ2005" unitRef="EUR">19816000</ifrs-gp:OtherReserves>
<ifrs-gp:RetainedEarningsAccumulatedLosses decimals="-3" contextRef="EJ2005" unitRef="EUR">-27731000</ifrs-gp:RetainedEarningsAccumulatedLosses>
<ifrs-gp:EquityAttributableToEquityHoldersOfParent decimals="-3" contextRef="EJ2005" unitRef="EUR">61136000</ifrs-gp:EquityAttributableToEquityHoldersOfParent>
<ifrs-gp:EquityTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">61136000</ifrs-gp:EquityTotal>
<ifrs-gp:PostEmploymentBenefitObligationNonCurrent decimals="-3" contextRef="EJ2005" unitRef="EUR">4606000</ifrs-gp:PostEmploymentBenefitObligationNonCurrent>
<ifrs-gp:DeferredTaxLiabilities decimals="-3" contextRef="EJ2005" unitRef="EUR">1542000</ifrs-gp:DeferredTaxLiabilities>
<ifrs-gp:TradeAndOtherPayablesNonCurrent decimals="-3" contextRef="EJ2005" unitRef="EUR">214000</ifrs-gp:TradeAndOtherPayablesNonCurrent>
<ifrs-gp:LiabilitiesNonCurrentTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">6362000</ifrs-gp:LiabilitiesNonCurrentTotal>
<ifrs-gp:OtherFinancialLiabilitiesCurrent decimals="-3" contextRef="EJ2005" unitRef="EUR">3361000</ifrs-gp:OtherFinancialLiabilitiesCurrent>
<ifrs-gp:CurrentTaxPayables decimals="-3" contextRef="EJ2005" unitRef="EUR">1136000</ifrs-gp:CurrentTaxPayables>
<ifrs-gp:TradeAndOtherPayablesCurrent decimals="-3" contextRef="EJ2005" unitRef="EUR">9568000</ifrs-gp:TradeAndOtherPayablesCurrent>
<ifrs-gp:LiabilitiesCurrentTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">14065000</ifrs-gp:LiabilitiesCurrentTotal>
<ifrs-gp:LiabilitiesTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">20427000</ifrs-gp:LiabilitiesTotal>
<ifrs-gp:EquityAndLiabilitiesTotal decimals="-3" contextRef="EJ2005" unitRef="EUR">81563000</ifrs-gp:EquityAndLiabilitiesTotal>
<ifrs-gp:RevenueTotalByFunction decimals="-3" contextRef="J2004" unitRef="EUR">7777000</ifrs-gp:RevenueTotalByFunction>
<ifrs-gp:CostOfSalesByFunction decimals="-3" contextRef="J2004" unitRef="EUR">1288000</ifrs-gp:CostOfSalesByFunction>
<ifrs-gp:GrossProfitByFunction decimals="-3" contextRef="J2004" unitRef="EUR">6489000</ifrs-gp:GrossProfitByFunction>
<ifrs-gp:MarketingAndDistributionCostsByFunction decimals="-3" contextRef="J2004" unitRef="EUR">134000</ifrs-gp:MarketingAndDistributionCostsByFunction>
<ifrs-gp:ResearchAndDevelopment decimals="-3" contextRef="J2004" unitRef="EUR">5443000</ifrs-gp:ResearchAndDevelopment>
<ifrs-gp:AdministrativeExpensesByFunction decimals="-3" contextRef="J2004" unitRef="EUR">4520000</ifrs-gp:AdministrativeExpensesByFunction>
<ifrs-gp:OperatingExpensesTotalByFunction decimals="-3" contextRef="J2004" unitRef="EUR">10097000</ifrs-gp:OperatingExpensesTotalByFunction>
<ifrs-gp:ProfitLossFromOperations decimals="-3" contextRef="J2004" unitRef="EUR">-3608000</ifrs-gp:ProfitLossFromOperations>
<ifrs-gp:FinanceCostsForNonFinancialActivities decimals="-3" contextRef="J2004" unitRef="EUR">162000</ifrs-gp:FinanceCostsForNonFinancialActivities>
<ifrs-gp:IncomeLossFromInvestments decimals="-3" contextRef="J2004" unitRef="EUR">202000</ifrs-gp:IncomeLossFromInvestments>
<ifrs-gp:ProfitLossBeforeTax decimals="-3" contextRef="J2004" unitRef="EUR">-3568000</ifrs-gp:ProfitLossBeforeTax>
<ifrs-gp:IncomeTaxExpenseIncome decimals="-3" contextRef="J2004" unitRef="EUR">21000</ifrs-gp:IncomeTaxExpenseIncome>
<ifrs-gp:ProfitLossAfterTaxFromContinuingOperations decimals="-3" contextRef="J2004" unitRef="EUR">-3589000</ifrs-gp:ProfitLossAfterTaxFromContinuingOperations>
<ifrs-gp:ProfitLoss decimals="-3" contextRef="J2004" unitRef="EUR">-3589000</ifrs-gp:ProfitLoss>
<ifrs-gp:ProfitLossAttributableToEquityHoldersOfParent decimals="-3" contextRef="J2004" unitRef="EUR">-3589000</ifrs-gp:ProfitLossAttributableToEquityHoldersOfParent>
<ifrs-gp:BasicEarningsLossPerShare decimals="2" contextRef="J2004" unitRef="EUR">-0.73</ifrs-gp:BasicEarningsLossPerShare>
<ifrs-gp:DilutedEarningsLossPerShare decimals="2" contextRef="J2004" unitRef="EUR">-0.73</ifrs-gp:DilutedEarningsLossPerShare>
<ifrs-gp:RevenueTotalByFunction decimals="-3" contextRef="J2005" unitRef="EUR">11240000</ifrs-gp:RevenueTotalByFunction>
<ifrs-gp:CostOfSalesByFunction decimals="-3" contextRef="J2005" unitRef="EUR">4829000</ifrs-gp:CostOfSalesByFunction>
<ifrs-gp:GrossProfitByFunction decimals="-3" contextRef="J2005" unitRef="EUR">6411000</ifrs-gp:GrossProfitByFunction>
<ifrs-gp:MiscellaneousOtherOperatingIncomeByFunction decimals="-3" contextRef="J2005" unitRef="EUR">78000</ifrs-gp:MiscellaneousOtherOperatingIncomeByFunction>
<ifrs-gp:OtherOperatingIncomeTotalByFunction decimals="-3" contextRef="J2005" unitRef="EUR">78000</ifrs-gp:OtherOperatingIncomeTotalByFunction>
<ifrs-gp:MarketingAndDistributionCostsByFunction decimals="-3" contextRef="J2005" unitRef="EUR">421000</ifrs-gp:MarketingAndDistributionCostsByFunction>
<ifrs-gp:ResearchAndDevelopment decimals="-3" contextRef="J2005" unitRef="EUR">6700000</ifrs-gp:ResearchAndDevelopment>
<ifrs-gp:AdministrativeExpensesByFunction decimals="-3" contextRef="J2005" unitRef="EUR">5737000</ifrs-gp:AdministrativeExpensesByFunction>
<ifrs-gp:MiscellaneousOtherOperatingExpensesByFunction decimals="-3" contextRef="J2005" unitRef="EUR">281000</ifrs-gp:MiscellaneousOtherOperatingExpensesByFunction>
<ifrs-gp:OperatingExpensesTotalByFunction decimals="-3" contextRef="J2005" unitRef="EUR">13139000</ifrs-gp:OperatingExpensesTotalByFunction>
<ifrs-gp:ProfitLossFromOperations decimals="-3" contextRef="J2005" unitRef="EUR">-6650000</ifrs-gp:ProfitLossFromOperations>
<ifrs-gp:FinanceCostsForNonFinancialActivities decimals="-3" contextRef="J2005" unitRef="EUR">369000</ifrs-gp:FinanceCostsForNonFinancialActivities>
<ifrs-gp:IncomeLossFromInvestments decimals="-3" contextRef="J2005" unitRef="EUR">368000</ifrs-gp:IncomeLossFromInvestments>
<ifrs-gp:ProfitLossBeforeTax decimals="-3" contextRef="J2005" unitRef="EUR">-6651000</ifrs-gp:ProfitLossBeforeTax>
<ifrs-gp:IncomeTaxExpenseIncome decimals="-3" contextRef="J2005" unitRef="EUR">-110000</ifrs-gp:IncomeTaxExpenseIncome>
<ifrs-gp:ProfitLossAfterTaxFromContinuingOperations decimals="-3" contextRef="J2005" unitRef="EUR">-6541000</ifrs-gp:ProfitLossAfterTaxFromContinuingOperations>
<ifrs-gp:ProfitLoss decimals="-3" contextRef="J2005" unitRef="EUR">-6541000</ifrs-gp:ProfitLoss>
<ifrs-gp:ProfitLossAttributableToEquityHoldersOfParent decimals="-3" contextRef="J2005" unitRef="EUR">-6541000</ifrs-gp:ProfitLossAttributableToEquityHoldersOfParent>
<ifrs-gp:BasicEarningsLossPerShare decimals="2" contextRef="J2005" unitRef="EUR">-0.6</ifrs-gp:BasicEarningsLossPerShare>
<ifrs-gp:DilutedEarningsLossPerShare decimals="2" contextRef="J2005" unitRef="EUR">-0.6</ifrs-gp:DilutedEarningsLossPerShare>
</xbrli:xbrl>
